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madden  
aggravate  (informal) annoy, craze, dement, derange, drive one crazy, drive one off one's head  (slang) drive one out of one's mind, drive one round the bend  (Brit. slang) drive one round the twist  (Brit. slang) drive one to distraction  (informal) enrage, exasperate, gall, get one's back up, get one's dander up  (informal) get one's goat  (slang) get one's hackles up, incense, inflame, infuriate, irritate, make one's blood boil, make one see red  (informal) make one's hackles rise, nark  (Brit., Austral., & N.Z. slang) piss one off  (taboo slang) provoke, put one's back up, raise one's hackles, unhinge, upset, vex 
 
Antonyms  
 appease, calm, mollify, pacify, soothe