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familiar 
1 accustomed, common, common or garden  (informal) conventional, customary, domestic, everyday, frequent, household, mundane, ordinary, recognizable, repeated, routine, stock, well-known 
2 familiar with  abreast of, acquainted with, at home with, au courant, au fait, aware of, conscious of, conversant with, introduced, knowledgeable, no stranger to, on speaking terms with, versed in, well up in 
3 amicable, buddy-buddy  (slang, chiefly U.S. & Canad.) chummy  (informal) close, confidential, cordial, easy, free, free-and-easy, friendly, hail-fellow-well-met, informal, intimate, near, open, palsy-walsy  (informal) relaxed, unceremonious, unconstrained, unreserved 
4 bold, disrespectful, forward, impudent, intrusive, overfree, presuming, presumptuous 
 
Antonyms  
 
1 infrequent, unaccustomed, uncommon, unfamiliar, unknown, unusual 
2 ignorant, unaccustomed, unacquainted, unfamiliar, uninformed, unskilled 
3 aloof, cold, detached, distant, formal, unfriendly